Genetics Of Cleft Lip And Palate Ppt To Pdf
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Van der Woude syndrome is a condition that affects the development of the face.
Van der Woude syndrome
Orofacial cleft OFC anomalies are amongst the most common congenital anomalies and the most common craniofacial anomalies. The genetic bases for many syndromic cases of OFC have been previously elucidated. Genetic associations have been described for nonsyndromic OFC as well. Importantly, etiology of OFC is known to involve interaction between genetic and environmental factors, including maternal nutrition and exposure to teratogenic agents. Furthermore, evidence points toward epigenetic as well as genetic factors influencing OFC etiology. Orofacial cleft OFC anomalies may be unilateral or bilateral and involve the lip, the palate, or both.
Facts about Cleft Lip and Cleft Palate
A cleft lip is an opening or split in the upper lip that occurs when developing facial structures in an unborn baby don't close completely. Cleft lip may be unilateral or bilateral. A baby with a cleft lip may also experience a cleft in the roof of the mouth cleft palate. A cleft palate is an opening or split in the roof of the mouth that occurs when the tissue doesn't fuse together during development in the womb. A cleft palate often includes a split cleft in the upper lip cleft lip but can occur without affecting the lip. Cleft lip and cleft palate are openings or splits in the upper lip, the roof of the mouth palate or both.
Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study Hungary, United States of America Pennsylvania, Texas , Spain, and Argentina. We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls.
Epidemiology of Cleft Lip and Palate
Click here to view a larger image. The lip forms between the fourth and seventh weeks of pregnancy. As a baby develops during pregnancy, body tissue and special cells from each side of the head grow toward the center of the face and join together to make the face. This joining of tissue forms the facial features, like the lips and mouth. A cleft lip happens if the tissue that makes up the lip does not join completely before birth.
Genetic etiology of cleft lip and cleft palate[J]. Article views PDF downloads 78 Cited by 0. Previous Article Next Article.
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