textbook of radiology and imaging david sutton volume 01 pdf

Textbook Of Radiology And Imaging David Sutton Volume 01 Pdf

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Harriet S. It has been several years since I reviewed the second edition of this textbook of medical imaging. Since the last review there have been significant changes in radiology and in the way that radiology and medicine, in general, are practiced.

Chom Nuhu D. Search for this author on: Google Scholar. A 45 year old man with malignant pleural mesothelioma had symptoms of prolonged cough, heamoptysis, breathlessness, weight loss and low grade persistent fever.

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Chom Nuhu D. Search for this author on: Google Scholar. A 45 year old man with malignant pleural mesothelioma had symptoms of prolonged cough, heamoptysis, breathlessness, weight loss and low grade persistent fever. The high prevalence of pulmonary tuberculosis in this environment, coupled with paucity of radiologists in rural areas to competently review his chest radiograph, resulted in making the wrong diagnosis of pulmonary tuberculosis PTB as against malignant pleural mesothelioma.

He was also wrongly treated for PTB for a period of nine months before referral to a Teaching Hospital. The correct diagnosis was made in a university teaching hospital where adequate specialized manpower was available. Distant metastasis to the liver was already observed at presentation. He was treated with six courses of chemotherapy Peclitaxel and Cisplastin and he did well before he was lost to follow-up.

Key words: Malignant pleural mesothelioma, PTB, liver metastasis. Mesothelioma or, more precisely malignant mesothelioma is a rare form of cancer that develops from transformed cells originating in the mesothelium, the protective lining that covers many of the internal organs of the body. There seems to be no association between mesothelioma and tobacco smoking, but smoking greatly increases the risk of developing other asbestos-induced cancers Stahel et al. Late diagnosis is therefore common, as it was in the index case.

This case is reported to reiterate the fact that malignant pleural mesothelioma and pulmonary tuberculosis share common clinical features and high index of suspicion is needed to avoid diagnostic pitfall. He presented to the FMC eleven months earlier with a five month history of cough, breathlessness, low-grade fever and weight loss. A chest x-ray done suggested features of pulmonary tuberculosis PTB which led to commencement of anti-TB drugs.

Following a nine month course of the anti-TB, deterioration of the clinical state of the patient as well as worsening of the radiological features on chest x-ray was noted. He was not a known hypertensive or diabetic patient. He neither smoked cigarette nor drank alcohol and has never worked in an asbestos factory.

He denied history of being a passive smoker prior to the onset of his illness. Clinical examination revealed an ill-looking middle aged man, asthenic, with puffy red eyes and facial swelling.

Massively distended neck veins as well as veins of the anterior chest wall were noted. There was right supraclavicular and left axillary lymphadenopathy. The nodes were averagely 1 cm in dimension, multiple, discrete, firm and freely mobile.

No tenderness was elicited over them and there was no finger clubbing. Chest examination revealed diminished right chest expansion associated with dull percussion note and decreased air entry in the upper, middle and lower zones of the right lung. The left lung field was clinically clear but the trachea was mildly buckled to the left. No remarkable findings were noted in the remaining systems. Investigations requested included Contrast-enhanced chest CT scan and CT-guided biopsy of the right pleura mass, abdominal ultrasound scan and retroviral screening.

The chest scanogram revealed a homogenous opacity of soft tissue density in the right lung apex, extending through the right hilum to the lower zone, obliterating the ipsilateral cardiac border Figure 1. The right main bronchus was compressed by the mass. There was right pleural fluid collection and non-homogenous opacities with background streakiness and nodularity in the remaining right lung fields. It extended to the adjacent lung parenchyma and hilum, encircling and narrowing the right main bronchus.

The distal trachea was bowed and displaced to the contralateral side. Associated nodular right pleural thickening and isodense lesion of fluid density in keeping with pleural effusion were also noted. Abdominal ultrasound scan revealed oval-shaped hypoechoic masses with uniform margins in the right lobe of the liver.

The largest measures 3. A radiological diagnosis of malignant mesothelioma of the right lung with liver metastasis was made.

CT-guided biopsy of the mass lesion confirmed the diagnosis. He was lost to follow-up after the chemotherapy presumably due to financial constraints.

Follow-up radiological assessment was not possible due to the aforementioned reason. Mesothelioma is a rare type of cancer that primarily affects the lining of the lungs, but can also affect the heart, abdomen and other organs CancerHelp UK, Mesotheliomas are classified into epitheliod, mixed, sarcomatoid and undifferentiated types, based on conventional histological examination.

The classification provides important prognostic information. Furthermore, differential diagnosis is directly related to histological type Corson, The Epitheloid form is the commonest type of the mesothelioma, which is the type diagnosed in the index case. Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer.

The incidence rate varies from one country to another, from a low rate of less than 1 per 1,, in Tunisia and Morocco, to the highest rate in Britain, Australia and Belgium, 30 per 1,, per year Bianchi and Bianchi, The incidence of malignant mesothelioma of the lungs currently ranges from about 7 to 40 per 1,, in industrialized Western Nations, depending on the amount of asbestos exposure during the past several decades Robinson and Lake, It occurs more often in men than in women and risk increases with age Bianchi and Bianchi, ; Robinson and Lake, The index case was a 45 year old man.

Symptoms and signs of malignant mesothelioma of the lungs may not appear until 20 to 50 years or more after exposure to asbestos Robinson and Lake, Shortness of breath, cough, heamoptysis and chest pain due to pleural effusion are the symptoms of pleural mesothelioma. If the cancer has caused obstructive symptoms or has spread beyond the mesothelium to other parts of the body, pain, dysphagia, odynophagia, or swelling of the neck or face may be experienced. Most of the enumerated symptoms, though non-specific, were found in this patient.

These symptoms coupled with chest x-ray and CT findings may make one to suspect the diagnosis but must be confirmed histologically as it was in the index case. This confirmation is necessary as malignant pleural mesothelioma simulates a number of other disease conditions other than PTB; these include: adenocarcinoma of the lung, non-small cell lung cancers, oath cell small cell lung cancer, drug-induced pulmonary reactions, actinomycosis, benign mesothelial hyperplasia, lymphoma, carcinoma metastatic to the pleural from Breast, ovarian, renal and colonic adenocarcinomas Zandwijk et al.

History of asbestos exposure exists in most cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos as it was in the index case CancerHelp UK, The non-specificity of the symptoms, signs and radiological features in patients with mesotheliomas has further complicated the issue of prognosis as most patients are only diagnosed at advanced stage.

Generally, the prognosis for malignant mesothelioma remains disappointing, although there have been some modest improvement in prognosis from newer chemotherapies and multimodality treatment Borasio et al. Treatment of malignant mesothelioma at earlier stages has a better prognosis, but cures are exceedingly rare Borasio et al. The epitheloid histologic type responds better to treatment and has a survival advantage over sarcomatoid histologic type Haber and Haber, Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions Stahel et al.

Chest x-ray is helpful and may reveal pleural thickening commonly seen after asbestos exposure. The radiographic appearance is of a well defined lobulated mass with a pleural base; the mass may be small or occupy most of the hemithorax.

On CT, large tumors may show areas of differential enhancement, and also areas of low attenuation due to necrosis Micheal and Simon, This patient had a CT-guided biopsy which confirmed the diagnosis.

Surgery, radiation therapy and chemotherapy are the treatment protocols available for mesothelioma. Surgery, by itself, has proved disappointing.

In one large series, the median survival with surgery including extrapleural pneumonectomy was only However; the research indicated varied success when used in combination with radiotherapy and chemotherapy.

Chemotherapy is the only singular treatment protocol that has been proven to improve survival in randomized and controlled trials. The index case had this combination therapy and his response was satisfactory before he was lost to follow-up. Treatment regimens involving immunotherapy have yielded variable results Gregoire, This was not contemplated due to the cost implication as this patient could not even commence chemotherapy until after 2 months, which is much cheaper than immunotherapy.

A case of malignant Pleural Mesothelioma with liver metastasis wrongly managed for pulmonary tuberculosis has been presented.

It emphasizes the role of imaging and high index of suspicion in the management of patients with malignant pleural mesothelioma. The need for adequate specialized manpower in every major hospital in Nigeria cannot be overemphasized, as that will enhance the quality of patient care and avert the diagnostic pitfalls initially encountered in the index case. Also, microbiological assessment of the sputum Sputum AFB will go a long way to establish a diagnosis of Tuberculosis and this must be done in all suspected cases of PTB before commencing treatment.

Authors have not declared any conflict of interest. Two-chamber intracardiac mesothelioma. Asian Cardiovasc Thorac Ann. Malignant mesothelioma: global incidence and relationship with asbestos. Industrial Health. Eur J. Cardiothoracic Surg. Retrieved — 08 — Corson JM Pathology of Diffuse Malignant Pleural Mesothelioma. Semin Thoracic Cardiovasc Surg. Gregoire M Cell Adh Migr.

Malignant mesothelioma: A Clinical Study of Cases. Arch Pathol Lab Med. Advances in malignant mesothelioma. J Thoracic. This article is published under the terms of the Creative Commons Attribution License 4. Reviewers Reviewers Guidelines. Editors Editors.

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Book Review| Volume 58, ISSUE 9, P, September 01, In the preface David Sutton said that he hoped to reflect “British Teaching Hospital Practice”.


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Textbook of Radiology and Imaging 7th Edition Volume 1 PDF – David Sutton

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